However, due to higher plasma levels in lower weight children, the starting and target dose in this group may be 10 mg/day. After 1 week at 10 mg/day, increase the dose to 20 mg/day. Pediatric (children and adolescents) - Initiate Fluoxetine Capsules 10 or 20 mg/day. Studies comparing fluoxetine 20, 40, and 60 mg/day to placebo indicate that 20 mg/day is sufficient to obtain a satisfactory response in Major Depressive Disorder in most cases. In controlled trials used to support the efficacy of fluoxetine, patients were administered morning doses ranging from 20 to 80 mg/day. The maximum fluoxetine dose should not exceed 80 mg/day. Administer doses above 20 mg/day once daily in the morning or twice daily (i.e., morning and noon). Consider a dose increase after several weeks if insufficient clinical improvement is observed. Fluoxetine Capsules Dosage and Administration Major Depressive DisorderĪdult - Initiate Fluoxetine Capsules 20 mg/day orally in the morning. When using Fluoxetine Capsules and olanzapine in combination, also refer to the Clinical Studies section of the package insert for Symbyax ®. Treatment resistant depression (Major Depressive Disorder in patients, who do not respond to 2 separate trials of different antidepressants of adequate dose and duration in the current episode).įluoxetine capsules monotherapy is not indicated for the treatment of depressive episodes associated with Bipolar I Disorder or the treatment of treatment resistant depression.Acute treatment of depressive episodes associated with Bipolar I Disorder.įluoxetine Capsules and Olanzapine in Combination are indicated for the treatment of: Acute treatment of Panic Disorder, with or without agoraphobia.Acute and maintenance treatment of binge-eating and vomiting behaviors in patients with moderate to severe Bulimia Nervosa.Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD).Acute and maintenance treatment of Major Depressive Disorder.Indications and Usage for Fluoxetine Capsulesįluoxetine capsules are indicated for the treatment of: When using fluoxetine and olanzapine in combination, also refer to Boxed Warning section of the package insert for Symbyax. Fluoxetine is not approved for use in children less than 7 years of age.Advise families and caregivers of the need for close observation and communication with the prescriber. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and for emergence of suicidal thoughts and behaviors.These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24 there was a reduction in risk with antidepressant use in patients aged 65 and older. Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies.